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Universal reaction: MTHFR3


Descriptive name:

5 10 methylenetetrahydrofolatereductase NADPH

Reaction:

2.0 h_c + mlthf_c + nadph_c ⇌ 5mthf_c + nadp_c

Metabolites:

Stoichiometry
BiGG ID
Name
1.0
5mthf_c
5-Methyltetrahydrofolate
-2.0
h_c
H+
-1.0
mlthf_c
5,10-Methylenetetrahydrofolate
1.0
nadp_c
Nicotinamide adenine dinucleotide phosphate
-1.0
nadph_c
Nicotinamide adenine dinucleotide phosphate - reduced

MTHFR3 in BiGG models:

Organism
Model
Methanosarcina barkeri str. Fusaro
iAF692
Geobacter metallireducens GS-15
iAF987
Plasmodium berghei
iAM_Pb448
Plasmodium cynomolgi strain B
iAM_Pc455
Plasmodium falciparum 3D7
iAM_Pf480
Plasmodium knowlesi strain H
iAM_Pk459
Plasmodium vivax Sal-1
iAM_Pv461
Homo sapiens
iAT_PLT_636
Cricetulus griseus
iCHOv1
Acinetobacter baumannii AYE
iCN718
Pseudomonas putida KT2440
iJN746
Mus musculus
iMM1415
Saccharomyces cerevisiae S288C
iMM904
Lactococcus lactis subsp. cremoris MG1363
iNF517
Synechocystis sp. PCC 6803
iSynCJ816
Bacillus subtilis subsp. subtilis str. 168
iYO844
Homo sapiens
RECON1
Homo sapiens
Recon3D

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External database links

  • RHEA: 19817, 19818, 19819, 19820
  • MetaNetX (MNX) Equation: MNXR101752
  • EC Number: 1.5.1.20
  • KEGG Reaction: R01224

Provided by MetaNetX (CC BY 4.0)

Old identifiers

    METFR, MTHFR1, MTHFR3

Latest BiGG Models publication:

King ZA, Lu JS, Dräger A, Miller PC, Federowicz S, Lerman JA, Ebrahim A, Palsson BO, and Lewis NE. BiGG Models: A platform for integrating, standardizing, and sharing genome-scale models (2016) Nucleic Acids Research 44(D1):D515-D522. doi:10.1093/nar/gkv1049


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